Isotopically Labeled Compounds
Medchemexpress LLC MPP+-d3 (iodide) | 207556-07-8 | 99.2% | 300.15 | 5 MG
MPP+-d3 (iodide) is deuterium labeled MPP+ (iodide). MPP+ iodide is a toxic metabolite of the neurotoxin MPTP, which causes Parkinson's disease symptoms in animal models by selectively destroying dopaminergic neurons in the substantia nigra. It is taken up by the dopamine transporter into dopaminergic neurons, where it exerts its neurotoxic action on mitochondria by affecting complex I of the respiratory chain. MPP+ iodide is also a high-affinity substrate for the serotonin transporter (SERT). This compound can be used as a tracer and as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Deuterium labeled compound.
- Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated for use as tracers in drug development.
- Has potential to affect pharmacokinetic and metabolic profiles of drugs.
Medchemexpress LLC L-Tyrosine-d4 | 62595-14-6 | 185.21 | 100 MG
L-Tyrosine-d4 is a deuterium labeled L-Tyrosine. L-Tyrosine is classified as a non-essential amino acid, and it can inhibit citrate synthase activity in the posterior cortex.
- Used as a tracer.
- Used as an internal standard for quantitative analysis by methods such as NMR, GC-MS, or LC-MS.
Cambridge Isotope Laboratories Cytidine phosphoramidite (U-15N3 98%) CP 95% 10 mg
Cytidine phosphoramidite (U-15N3 98%) CP 95% 10 mg
Medchemexpress LLC CER7-2'R,6R-d9 | 2260670-24-2 | 99.0% | 578.95 | 1 MG
CER7-2'R,6R-d9 is a deuterium labeled CER7-2'R,6R. It is intended for research use only and can be utilized as a tracer and as an internal standard for quantitative analysis through methods like NMR, GC-MS, or LC-MS. Deuteration, which involves incorporating stable heavy isotopes of hydrogen (deuterium), carbon, and other elements into drug molecules, has shown potential in influencing the pharmacokinetic and metabolic profiles of drugs.
- Deuterium labeled CER7-2'R,6R
- Intended for research use only
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Cambridge Isotope Laboratories NAT (N-nitrosoanatabine) (unlabeled) 2 mg/mL in acetonitrile 1 2 mL
NAT (N-nitrosoanatabine) (unlabeled) 2 mg/mL in acetonitrile 1 2 mL
Medchemexpress LLC Diclofenac-d4 sodium | 154523-54-3 | C14H6D4Cl2NNaO2 | 1 MG
Diclofenac-d4 (sodium) is the deuterium labeled Diclofenac sodium. It is a potent and nonselective anti-inflammatory agent that acts as a COX inhibitor. It also induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade. This product is for research use only and not for sale to patients.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Acts as a potent and nonselective anti-inflammatory agent
- Inhibits COX enzymes
- Induces apoptosis of neural stem cells (NSCs)
Cayman Chemical Amlodipine-d4 (maleate), Purity: ≥99% deuterated forms (d1-d4), CAS: 1185246-15-4, 5 mg
An internal standard for the quantification of amlodipine by GC- or LC-MS
Cambridge Isotope Laboratories OXALIC ACID, DISODIUM SALT (1,2-13C2, 99%), 1 G, 260429-91-2
OXALIC ACID, DISODIUM SALT (1,2-13C2, 99%), 1 G, 260429-91-2
Cayman Chemical Milrinone-d3, Purity: ≥99% deuterated forms (d1-d3), CAS: 2749393-50-6, 1 mg
An internal standard for the quantification of milrinone by GC- or LC-MS
Medchemexpress LLC Methyl 4-hydroxybenzoate-d4 | 362049-51-2 | 156.17 | 5 MG
Methyl paraben-d4 is the deuterium-labeled form of methyl paraben, which is the methyl ester of p-hydroxybenzoic acid. Isolated from the barks of Tsuga dumosa, methyl paraben is a standardized chemical allergen. It serves as a stable, non-volatile antimicrobial preservative in various products. Its physiological effect involves increased histamine release and cell-mediated immunity.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Stable heavy isotopes incorporated into drug molecules largely for quantitation during drug development.
- Deuteration has potential to affect pharmacokinetic and metabolic profiles of drugs.
Medchemexpress LLC 4-pyridoxic acid-d3 | 1435934-03-4 | 98.8% | 186.18 g/mol | C8H6D3NO4 | 5 MG
4-Pyridoxic acid-d3 is the deuterium-labeled analog of 4-pyridoxic acid, a catabolic product of vitamin B6. It is provided as a stable isotope reference standard for use in analytical, pharmacokinetic, and quantitative assays.
- Deuterium-labeled internal standard for quantitative assays.
- High purity (98.8%).
- Soluble in DMSO at ~5 mg/mL; requires ultrasonic warming.
- Recommended storage under nitrogen; in solution -80°C for up to 6 months, -20°C for up to 1 month.
- Supplied in a small, analytically appropriate quantity for reference use.
Medchemexpress LLC GW2580-d6 | 2733770-48-2 | 98.4% | 372.45 | 1 ML
GW2580-d6 is a deuterium-labeled version of GW2580, an orally bioavailable and selective inhibitor of c-Fms kinase. It completely inhibits human cFMS kinase in vitro at a concentration of 0.06 μM. This compound acts as a competitive inhibitor of ATP binding to the cFMS kinase, thereby inhibiting colony-stimulating-factor-1 signaling. Intended for research use only, it appears as a white to off-white solid.
- Stable isotope: Contains deuterium labeling, useful as a tracer and internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- High purity: 98.36% purity ensures reliable experimental results.
- Selective inhibition: Potently inhibits c-Fms kinase, impacting colony-stimulating-factor-1 signaling.
- Orally bioavailable: The unlabeled compound, GW2580, is orally bioavailable.